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Pomalidomide 4PEG2
PubMed PMID: 26259519
acting as an androgen receptor degrader
and reactivation from latency
Oksenberg D
Ispinesib (SB-715992) st N-oxide Pomalidomide 4PEG2Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be
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